Published on November 17th 2021 in Microbiology, Immunology and Pathology Bothe et al. presented for the first time a direct comparison of three of the most commonly used laxatives, i.e., Macrogol, Bisacodyl, and Lactulose regarding their potential beneficial effects on the gut microbiome.
A computer-controlled model of the proximal large intestine (TIM-2) with a metabolically active, anaerobic microbiota of human origin was used to investigate the effects of the different laxatives. The laxatives were applied over 5 consecutive days in their usual daily dose to treat constipation in adults. The data clearly demonstrated that in contrast to Macrogol and Bisacodyl only Lactulose had a strong prebiotic effect on Bifidobacteria and Lactobacilli indicating a beneficial support for the gut microbiota of constipated patients.
Reference: Bothe MK, et al. Microbiol Immunol Pathol 2021;2(3):1.